INDUCTION OF MICRONUCLEI BY BLEOMYCIN IN G0 HUMAN-LYMPHOCYTES .1. DOSE-RESPONSE AND DISTRIBUTION

被引：28

作者：

HOFFMANN, GR ^{[1
]}

COLYER, SP ^{[1
]}

LITTLEFIELD, LG ^{[1
]}

机构：

[1] OAK RIDGE ASSOCIATED UNIV,DIV MED SCI,OAK RIDGE,TN 37830

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 1993年 / 21卷 / 02期

关键词：

CYTOCHALASIN-B; CYTOKINESIS-BLOCK ASSAY;

D O I：

10.1002/em.2850210206

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The cytokinesis-block micronucleus assay was used to investigate the induction of chromosomal damage by bleomycin in G0 human lymphocytes. A dose-dependent increase in the frequency of micronuclei was observed in binucleate cells, and the frequency approached 0.5 micronuclei per cell at the highest dosage tested. The distribution of micronuclei among cells was overdispersed, rather than fitting a Poisson distribution. Even at the highest dosage, more than two-thirds of the cells did not contain micronuclei, while some cells were highly damaged, containing more than 4 micronuclei per cell.

引用

页码：130 / 135

页数：6

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