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HETEROTRANSPLANTATION OF HUMAN CRANIOPHARYNGIOMAS IN ATHYMIC NUDE-MICE
被引：41
作者：
BULLARD, DE
BIGNER, DD
机构：
来源：
关键词：
D O I：
10.1227/00006123-197904000-00006
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Surgical biopsies from 2 human craniopharyngiomas were transplanted subcutaneously into 6 athymic 'nude' mice. Morphologically characteristic craniopharyngiomas grew in 5 of these animals. In 4 animals growth was sufficient to allow transplantation into a second generation of animals. In all, 11 craniopharyngiomas were present at autopsy in the 14 animals into which the tumors had been transplanted. The tumors that grew in the animals had the same adamantinomatous architecture, epithelial nests, and keratinized nodules that were present in the original surgical sample and that are characteristic of human craniopharyngiomas. It may be possible to study growth characteristics and therapeutic sensitivities of human craniopharyngiomas growing in 'nude' mice.
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页码：308 / 314
页数：7
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