MECHANISTIC STUDIES ON PREGNENE SIDE-CHAIN CLEAVAGE ENZYME (17-ALPHA-HYDROXYLASE-17,20-LYASE) USING O-18

被引：42

作者：

MILLER, SL ^{[1
]}

WRIGHT, JN ^{[1
]}

CORINA, DL ^{[1
]}

AKHTAR, M ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON,DEPT BIOCHEM,MED & BIOL SCI BLDG,BASSETT CRESCENT E,SOUTHAMPTON SO9 3TU,HANTS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 03期

关键词：

D O I：

10.1039/c39910000157

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the conversion of pregnenolone 1 into dehydroisoandrosterone 3 and 3-beta-hydroxyandrosta-5,16-diene 5 an atom of oxygen from O2 is incorporated into the side chain released as acetate; during the conversions the C-21 methyl hydrogens of the precursor are not disturbed, the status of 16-alpha and 17-alpha hydrogen atoms during the conversions is also defined.

引用

页码：157 / 159

页数：3

共 14 条

[1] CHEMICAL AND ENZYMIC STUDIES ON CHARACTERIZATION OF INTERMEDIATES DURING REMOVAL OF 14-ALPHA-METHYL GROUP IN CHOLESTEROL-BIOSYNTHESIS - USE OF 32-FUNCTIONALIZED LANOSTANE DERIVATIVES
AKHTAR, M
ALEXANDER, K
BOAR, RB
MCGHIE, JF
BARTON, DHR
[J]. BIOCHEMICAL JOURNAL, 1978, 169 (03) : 449 - 463
[2] MECHANISTIC STUDIES ON C-19 DEMETHYLATION IN ESTROGEN BIOSYNTHESIS
AKHTAR, M
CALDER, MR
CORINA, DL
WRIGHT, JN
[J]. BIOCHEMICAL JOURNAL, 1982, 201 (03) : 569 - 580
[3] A ONE-STEP PROCEDURE FOR PREPARATION OF TERTIARY ALPHA-KETOLS FROM CORRESPONDING KETONES
GARDNER, JN
CARLON, FE
GNOJ, O
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1968, 33 (08) : 3294 - &
[4] IDENTIFICATION OF 16-DEHYDROPREGNENOLONE AS AN INTERMEDIATE IN 16-ANDROSTENE BIOSYNTHESIS IN NEONATAL PORCINE TESTICULAR MICROSOMES
KWAN, TK
TAYLOR, NF
WATSON, D
GOWER, DB
[J]. FEBS LETTERS, 1984, 174 (01) : 173 - 178
[5] LYNN WS, 1958, J BIOL CHEM, V232, P1015
[6] STEROIDAL SAPOGENINS
MARKER, RE
WAGNER, RB
ULSHAFER, PR
WITTBECKER, EL
GOLDSMITH, DPJ
RUOF, CH
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1947, 69 (09) : 2167 - 2230
[7] NAKAJIN S, 1981, J BIOL CHEM, V256, P3871
[8] CYTOCHROME B5 PROMOTES THE SYNTHESIS OF DELTA-16-C-19 STEROIDS BY HOMOGENEOUS CYTOCHROME-P-450 C-21 SIDE-CHAIN CLEAVAGE FROM PIG TESTIS
NAKAJIN, S
TAKAHASHI, M
SHINODA, M
HALL, PF
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 132 (02) : 708 - 713
[9] NAKANO C, 1968, BIOCHIM BIOPHYS ACTA, V152, P186
[10] INADEQUACY OF 19-ALDEHYDE AS AN INTERMEDIATE IN ESTROGEN BIOSYNTHESIS
OSAWA, Y
SHIBATA, K
[J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1974, 5 (04) : 315 - 315

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