DIFFERENTIAL INHIBITION BY NMDA ANTAGONISTS OF RAPID TOLERANCE TO, AND CROSS-TOLERANCE BETWEEN, ETHANOL AND CHLORDIAZEPOXIDE

被引：43

作者：

KHANNA, JM ^{[1
]}

MIHIC, SJ ^{[1
]}

WEINER, J ^{[1
]}

SHAH, G ^{[1
]}

WU, PH ^{[1
]}

KALANT, H ^{[1
]}

机构：

[1] ADDICT RES FDN, TORONTO M5S 2S1, ONTARIO, CANADA

来源：

BRAIN RESEARCH | 1992年 / 574卷 / 1-2期

关键词：

N-METHYL-D-ASPARTATE ANTAGONISTS; ETHANOL; CHLORDIAZEPOXIDE; TOLERANCE;

D O I：

10.1016/0006-8993(92)90824-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have recently found that the non-competitive N-methyl-D-aspartate (NMDA) antagonists, (+)MK-801 and ketamine, block the development of rapid tolerance to ethanol. In the present report we show that they also block rapid cross-tolerance from chlordiazepoxide to ethanol as well as ethanol to chlordiazepoxide. However, NMDA antagonists fail to block the development of rapid tolerance to chlordiazepoxide. Our results suggest that NMDA antagonists may affect not only the acquisition of rapid tolerance or cross-tolerance to sedatives but also the ability to express that tolerance or cross-tolerance, depending on the drugs used. It is also possible that the phenomena of rapid tolerance and rapid cross- tolerance have basic differences not previously reported in the literature.

引用

页码：251 / 256

页数：6

共 18 条

[1] EFFECTS OF THE NMDA RECEPTOR CHANNEL ANTAGONISTS CPP AND MK801 ON HIPPOCAMPAL FIELD POTENTIALS AND LONG-TERM POTENTIATION IN ANESTHETIZED RATS [J].