A PROPOSED MECHANISM FOR EFFECTS OF DIET ON MAMMARY-CANCER

被引：18

作者：

CARROLL, KK

PARENTEAU, HI

机构：

[1] Human Nutrition Centre, Department of Biochemistry, University of Western Ontario, London, Ontario

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1991年 / 16卷 / 02期

关键词：

D O I：

10.1080/01635589109514146

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Growth and development of mammary glandular parenchyma appear to be strongly influenced by the associated adipose tissue. Because fat is the major form of energy storage in the body, any changes in energy balance will be reflected in the weight of adipose tissue to a greater extent than in body weight as a whole. High-fat diets tend to encourage energy storage and may promote mammary cancer by increasing the amount of adipose tissue in the gland. The intimate association of adipose and glandular tissue would facilitate the transfer of any growth-promoting substances, such as polyunsaturated fatty acids, eicosanoids, estrogens, or other growth factors, from the adipose to the glandular tissue. Conversely, low-fat diets or restriction of food intake may decrease the risk of mammary cancer by reducing the amount of adipose tissue and thus reducing exposure of the glandular tissue to such growth-promoting substances.

引用

页码：79 / 83

页数：5

共 42 条

[1] Tannenbaum A., Nutrition and Cancer, The Physiopathology of Cancer, pp. 517-562, (1959)
[2] Carroll K.K., Khor H.T., Dietary Fat in Relation to Tumorigenesis, Prog Biochem Pharmacol, 10, pp. 308-353, (1975)
[3] Carroll K.K., Experimental Evidence of Dietary Factors and Hormone-dependent Cancers, Cancer Res, 35, pp. 3374-3383, (1975)
[4] Diet, Nutrition, and Cancer, (1982)
[5] Rogers A.E., Lee S.Y., Chemically-Induced Mammary Gland Tumors in Rats: Modulation by Dietary Fat, Progress in Clinical Biological Research, Dietary Fat and Cancer, 222, pp. 255-282, (1986)
[6] Cohen L.A., Dietary Fat and Mammary Cancer, Diet, Nutrition and Cancer
[7] A Critical Evaluation. Macronutrients and Cancer, 1, pp. 77-100, (1986)
[8] Freedman L.S., Clifford C., Messina M., Analysis of Dietary Fat, Calories, Body Weight, and the Development of Mammary Tumors in Rats and Mice: A Review, Cancer Res, 50, pp. 5710-5719, (1990)
[9] Lea A.J., Dietary Factors Associated With Death-Rates From Certain Neoplasms in Man, Lancet, 2, pp. 332-333, (1966)
[10] Wynder E.L., Hyams L., Shigematsu T., Correlations of International Cancer Death Rates. An Epidemiological Exercise, Cancer, 20, pp. 113-126, (1967)

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