学术探索
学术期刊
新闻热点
数据分析
智能评审

MECHANISMS IN IGE-DEPENDENT ANAPHYLAXIS TO ANESTHETIC DRUGS

被引：21
作者：
BALDO, BA
FISHER, MM
机构：
[1] Kolling Institute of Medical Research, Royal North Shore Hospital of Sydney, St Leonards
[2] Intensive Therapy Unit, Royal North Shore Hospital of Sydney, St Leonards
来源：
ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION | 1993年 / 12卷 / 02期
关键词：
D O I：
10.1016/S0750-7658(05)81022-6
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
The discovery of IgE antibodies to neuromuscular blocking drugs, to thiopentone and narcotics, particularly morphine, reinforced earlier beliefs formed from skin test and other clinical findings that many << anaphylactoid >> reactions to drugs were true type 1 immediate hypersensitivity reactions. Immunochemical studies established the fine structural specificities of the drug-reactive IgE antibodies and provided an explanation in molecular terms for a number of observed clinical cross-reactions. Subtleties in interpreting relationships between skin tests and IgE radioimmunoassays are pointed out and mechanisms of drug-induced mediator release, persistence of IgE antibodies and the nature of the sensitizing sources are discussed.
引用
收藏
页码：131 / 140
页数：10
相关论文
共 54 条
  • [1] Assem, Neuromuscular blocking drugs (pp 299–312), Allergic reactions to drugs. Handbook of experimental pathology, 63, (1983)
  • [2] Baldo, Drug allergies : questioning immunological dogma, Today's Life Science, 1, pp. 20-27, (1989)
  • [3] Baldo, Immunochemical perspectives of allergy : in the steps of Karl Landsteiner (pp 1–10), Molecular approaches to the study of allergens. Monographs in allergy, 28, (1990)
  • [4] Baldo, Fisher, Substituted ammonium ions as allergenic determinants in drug allergy, Nature, 306, pp. 262-264, (1983)
  • [5] Baldo, Fisher, Anaphylaxis to muscle relaxant drugs : cross-reactivity and molecular basis of binding of IgE antibodies detected by radioimmunoassay, Mol Immunol, 20, pp. 1393-1400, (1983)
  • [6] Baldo, Fisher, Detection of serum IgE antibodies that react with alcuronium and tubocurarine after life-threatening reactions to muscle relaxant drugs, Anaesth Intensive Care, 11, pp. 194-197, (1983)
  • [7] Baldo, Fisher, Diagnosis of IgE-dependent anaphylaxis to neuromuscular blocking drugs, thiopentone and opioids, Ann Fr Anesth Réanim, 12, pp. 173-181, (1993)
  • [8] Baldo, Fisher, Harle, Allergy to thiopentone, Clin Rev Allergy, 9, pp. 295-308, (1991)
  • [9] Baldo, Harle, Drug allergenic determinants (pp 11–51), Molecular approaches to the study of allergens. Monograph in allergy, 28, (1990)
  • [10] Clarke, Dundee, Garrett, McArdle, Sutton, Adverse reactions to intravenous drugs. A survey of 100 reports, Br J Anaesth, 47, pp. 575-585, (1975)
123456