DELAYED HISTOLOGIC DAMAGE AND NEURON DEATH IN THE SUBSTANTIA-NIGRA-RETICULATA FOLLOWING TRANSIENT FOREBRAIN ISCHEMIA DEPENDS ON THE EXTENT OF INITIAL STRIATAL INJURY

被引：29

作者：

SAJI, M ^{[1
]}

VOLPE, BT ^{[1
]}

机构：

[1] CORNELL UNIV, SCH MED,BURKE INST MED RES,DEPT NEUROL & NEUROSCI, 785 MAMARONECK AVE, WHITE PLAINS, NY 10605 USA

来源：

NEUROSCIENCE LETTERS | 1993年 / 155卷 / 01期

关键词：

STRIATUM; GLOBUS PALLIDUS; SUBSTANTIA-NIGRA-RETICULATA; ISCHEMIA; DELAYED DEGENERATION;

D O I：

10.1016/0304-3940(93)90670-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transient forebrain ischemia in normoglycemic, normotensive rodents reproducibly causes selectively vulnerable neurons in the striatum to degenerate within 24 h. Neurons in the substantia nigra reticulata (SNR) are resistant to this acute process. Histologic evidence demonstrates that the combination of acute ischemic injury to the caudate nucleus and globus pallidus is associated with delayed neuron degeneration in the SNR that matures at 3 weeks after reperfusion. Ischemia, like certain ablative neurotoxin lesions, may provoke degenerative, perhaps transneuronal events that continue to evolve long after the initial insult.

引用

页码：47 / 50

页数：4

共 29 条

[1] THE FUNCTIONAL-ANATOMY OF BASAL GANGLIA DISORDERS [J].