ISOLATED HEARTS FROM COPPER-DEFICIENT RATS EXHIBIT IMPROVED POSTISCHEMIC CONTRACTILE PERFORMANCE

被引:13
作者
ALLEN, CB [1 ]
SAARI, JT [1 ]
机构
[1] USDA ARS,GRAND FORKS HUMAN NUTR RES CTR,GRAND FORKS,ND 58202
关键词
HEART; ISCHEMIA-REPERFUSION; COPPER; RATS; FREE RADICAL;
D O I
10.1093/jn/123.11.1794
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Dietary copper deficiency affects a number of enzymes, the function of which may influence the outcome of myocardial ischemia-reperfusion injury. Male weanling rats were fed diets that were adequate (>5 mg/kg) or deficient (<1 mg/kg) in copper. After 4 wk, the rats' hearts were isolated and used to study the effects of ischemia-reperfusion on intraventricular developed pressure (DevP), positive and negative rates of intraventricular pressure change (+dp/dt and -dp/dt) and release of lactate dehydrogenase and creatine kinase from the heart. The ischemia-perfusion protocol included a 15-min equilibration period, 30 min of warm, total ischemia and reperfusion for 30 min. Preischemic hearts from copper-deficient rats produced lower DevP than hearts from copper-adequate rats at all levels of preload. However, postischemic recovery of DevP was significantly greater in the hearts of the copper-deficient group. Furthermore, the postischemic patterns of lactate dehydrogenase and creatine kinase release in the two groups were significantly different. These findings indicate that, although dietary copper deficiency adversely affects a number of enzymatic systems, the functional recovery of hearts subjected to ischemia-reperfusion injury is improved when the diet is restricted in copper.
引用
收藏
页码:1794 / 1800
页数:7
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