SUBTYPE ANALYSIS OF HTLV-1 IN PATIENTS WITH HTLV-1 UVEITIS

被引：22

作者：

ONO, A

MIURA, T

ARAKI, S

YAMAGUCHI, K

TAKATSUKI, K

MORI, S

HAYAMI, M

MOCHIZUKI, M

WATANABE, T

机构：

[1] UNIV TOKYO, INST MED SCI, DEPT PATHOL, MINATO KU, TOKYO 108, JAPAN

[2] KURUME UNIV, SCH MED, DEPT OPHTHALMOL, KURUME, FUKUOKA 830, JAPAN

[3] MIYATA EYE HOSP, MIYAKONOJO, MIYAZAKI 885, JAPAN

[4] KUMAMOTO UNIV, SCH MED, DEPT INTERNAL MED, KUMAMOTO 860, JAPAN

[5] KYOTO UNIV, INST VIRUS RES, SAKYO KU, KYOTO 606, JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1994年 / 85卷 / 08期

关键词：

HTLV-1; UVEITIS; ATL; LTR SEQUENCE; PHYLOGENIC SUBTYPE;

D O I：

10.1111/j.1349-7006.1994.tb02945.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The hypothesis that HTLV-1 uveitis, a recently identified disease entity associated with human T-cell leukemia virus type I (HTLV-1), is caused by a specific subtype of the virus was tested. The nucleotide sequences of the long terminal repeat of HTLV-1 from five patients with HTLV-1 uveitis (HU) and four with adult T-cell leukemia were phylogenetically analyzed. Our results showed that both subtypes which had been identified in Japan were associated with HU, indicating that there was no difference in pathogenicity between these phylogenetic subtypes. One of the subtypes was more frequently isolated in Okinawa than in Kyushu, suggesting a bias in the prevalence of each subtype among the inhabitants of these two areas of Japan.

引用

页码：767 / 770

页数：4

共 30 条

[1] SEQUENCE VARIANTS OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I FROM PATIENTS WITH TROPICAL SPASTIC PARAPARESIS AND ADULT T-CELL LEUKEMIA DO NOT DISTINGUISH NEUROLOGICAL FROM LEUKEMIC ISOLATES [J].