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NUCLEATION OF MICROTUBULE ASSEMBLY BY A GAMMA-TUBULIN-CONTAINING RING COMPLEX

被引：713
作者：
ZHENG, YX [1 ]
WONG, ML [1 ]
ALBERTS, B [1 ]
MITCHISON, T [1 ]
机构：
[1] UNIV CALIF SAN FRANCISCO, DEPT PHARMACOL, SAN FRANCISCO, CA 94143 USA
来源：
NATURE | 1995年 / 378卷 / 6557期
关键词：
D O I：
10.1038/378578a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The highly conserved protein gamma-tubulin is required for microtubule nucleation in vivo. When viewed in the electron microscope, a highly purified gamma-tubulin complex from Xenopus consisting of at least seven different proteins is seen to have an open ring structure. This complex acts as an active microtubule-nucleating unit which can cap the minus ends of microtubules in vitro.
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页码：578 / 583
页数：6
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