BERBERINE - COMPLEX WITH DNA

被引：80

作者：

KREY, AK

HAHN, FE

机构：

[1] Department of Molecular Biology, Walter Reed Army Institute of Research, Washington

来源：

SCIENCE | 1969年 / 166卷 / 3906期

关键词：

D O I：

10.1126/science.166.3906.755

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A complex of calf-thymus DNA with berberine sediments in the analytical ultracentrifuge. The DNA produced systematic changes in the absorption spectrum of berberine which suggest that single alkaloid molecules bind to DNA. Flow dichroism of purines and pyrimidines and of berberine in the complex with DNA had the same signs and magnitudes. Berberine shifted the thermal strand separation profile of DNA to higher temperatures. Therefore, the alkaloid forms a complex with DNA, probably by intercalation.

引用

页码：755 / &

共 23 条

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