In a double blind study, different combinations of gestagens were given to four groups of mothers 6 to 10 weeks post partum (Lyndiol 2.5; Lyndiol 1.0; Lynestrenol alone; and Deladroxate injections). A fifth group (control) was given a placebo. Follow-up was done until weaning. The criteria used in evaluating the clinical results were: age at supplementation, subjective impressions of the mothers, amount of milk yield as obtained by mechanical suction and test feeding, feed-to-weight adequacy (i.e., the adequacy of a test feed in relation to baby's weight), infant growth curve, and percentage changes in infant's weight with age. The average amount of milk yield as obtained by mechanical suction and the feed-to-weight adequacy was found to be the two least objectionable parameter in the lactation study. This also applies to the percentage changes in infant weight before the start of supplementation. The small-dose Lynestrenol pill alone showed as far as influence on lactation is concerned, the best results as regards the five criteria combined, while the most objectionable were the high-dose medications, whether pill or injection. © 1969.
