REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF KETOXIME ANALOGS OF BETA-ADRENERGIC BLOCKERS

被引：4

作者：

PROKAI, L ^{[1
]}

SIMAY, A ^{[1
]}

BODOR, N ^{[1
]}

机构：

[1] UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL PHARM,CTR DRUG DISCOVERY,BOX J-497,GAINESVILLE,FL 32610

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 541卷 / 1-2期

关键词：

D O I：

10.1016/S0021-9673(01)96020-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Reversed-phase high-performance liquid chromatography of arloxyalkylaminoketone-oximes is optimized by implementing bonded-phase (C8 and C18) column packings deactivated for basic compounds, and competing base as mobile phase additive. The retention of Z isomers is prolonged because of intramolecular hydrogen bonding. The selectivity coefficient for the separation of E and Z compounds is influenced by internal constraints and intramolecular interaction of polar functional groups.

引用

页码：469 / 473

页数：5

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