ISOLATION AND CHARACTERIZATION OF A TRANSPOSON-INDUCED CYTOTOXIN-DEFICIENT MUTANT OF PSEUDOMONAS-AERUGINOSA

被引：3

作者：

BOPP, LH

BALTCH, AL

HAMMER, MC

FRANKE, MA

SMITH, RP

LUTZ, F

机构：

[1] DEPT VET AFFAIRS MED CTR,INFECT DIS SECT,113 HOLLAND AVE,ALBANY,NY 12208

[2] NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,BACTERIOL LAB,ALBANY,NY 12201

[3] UNION UNIV,ALBANY,NY 12208

[4] UNIV GIESSEN,INST PHARMACOL & TOXICOL,W-6300 GIESSEN,GERMANY

来源：

INFECTION AND IMMUNITY | 1991年 / 59卷 / 02期

关键词：

D O I：

10.1128/IAI.59.2.708-711.1991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In order to provide a better system for investigating the role of cytotoxin in pathogenesis, we mutated wild-type Pseudomonas aeruginosa PA158 by introducing a transposon. The resulting pool of mutants was screened for cytotoxin-deficient strains. One mutant strain, PA114F5, was compared with PA158. Except for cytotoxin production and antibiotic resistance (specified by the transposon), the two strains appear isogenic. This mutant strain should be useful in further clarifying the role of cytotoxin in pathogenesis.

引用

页码：708 / 711

页数：4

共 51 条

[1]

BALTCH AL, 1977, AM J MED SCI, V274, P119, DOI 10.1097/00000441-197709000-00002

[2] PRODUCTION OF CYTOTOXIN BY CLINICAL STRAINS OF PSEUDOMONAS-AERUGINOSA [J].