INDUCTION OF AUTOREACTIVE B-CELLS ALLOWS PRIMING OF AUTOREACTIVE T-CELLS

被引：237

作者：

LIN, RH

MAMULA, MJ

HARDIN, JA

JANEWAY, CA

机构：

[1] YALE UNIV, SCH MED, HOWARD HUGHES MED INST, NEW HAVEN, CT 06510 USA

[2] YALE UNIV, SCH MED, DEPT MED, RHEUMATOL SECT, NEW HAVEN, CT 06510 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1991年 / 173卷 / 06期

关键词：

D O I：

10.1084/jem.173.6.1433

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A novel mechanism for breaking T cell self tolerance is described. B cells induced to make autoantibody by immunization of mice with the non-self protein human cytochrome c can present the self protein mouse cytochrome c to autoreactive T cells in immunogenic form. This mechanism of breaking T cell self tolerance could account for the role of foreign antigens in breaking not only B cell but also T cell self tolerance, leading to sustained autoantibody production in the absence of the foreign antigen.

引用

页码：1433 / 1439

页数：7

共 37 条

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