COMPARATIVE EXPERIMENTAL VIRAL LABYRINTHITIS

被引:17
作者
DAVIS, LE
机构
关键词
deafness; inner ear infections; vertigo; viral labyrinthitis;
D O I
10.1016/0196-0709(90)90116-D
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Because of difficulties in studying acute deafness and vertigo in humans, animal models of viral labyrinthitis have played an important role in increasing our understnding of low viruses damage the inner ear. Investigators have been able to correlate viral labyrinthine infection to histopathologic changes and electrophysiologic consequences in experimental animals. Experimental viral labyrinthitis studies have convincingly demonstrated the selective vulnerability of inner ear cell types to different viruses. These findings are relatively consistent across animal species for many viruses. By understanding the pathogenesis of viral labyrinthitis in an animal model, we may learn how better to prevent or treat virus-induced deafness and vertigo in humans. © 1990.
引用
收藏
页码:382 / 388
页数:7
相关论文
共 47 条
[1]  
Davis, Johnsson, Kornfeld, Cytomegalovirus labyrinthitis in an infant: Morphological, virological, and immunofluorescent studies, J Neuropathol Exp Neurol, 40, pp. 9-19, (1981)
[2]  
Grillner, Forsgren, Barr, Et al., Outcome of rubella during pregnancy with special reference to the 17th–24th weeks of gestation, Scand J Infect Dis, 15, pp. 321-325, (1983)
[3]  
Westmore, Pickard, Stern, Isolation of mumps virus from the inner ear after sudden deafness, Br Med J, 1, pp. 14-15, (1979)
[4]  
Lindsay, Hemenway, Inner ear pathology due to measles, Ann Otol Rhinol Laryngol, 63, pp. 754-771, (1954)
[5]  
Davis, Johnsson, Viral infections of the inner ear Clinical virologic and pathologic studies in humans and animals, American Journal of Otolaryngology, 4, pp. 347-362, (1983)
[6]  
Fox, Hall, Viruses in Families: Surveillance of Families as a Key to Epidemiology of Virus Infections, pp. 1-441, (1980)
[7]  
Craft, Hilding, Virus-like particles in the spiral ganglion of the guinea pig cochlea, Science, 162, pp. 1485-1487, (1968)
[8]  
Craft, Hilding, Bhatt, Et al., Spiral ganglion virus-like particles of guinea pigs, Adv Otorhinolaryngol, 20, pp. 178-190, (1973)
[9]  
Lohle, Kistler, Riede, Et al., Virus particles in the cochlear spiral ganglion of guinea pigs, Acta Otolaryngol (Stockh), 94, pp. 233-239, (1982)
[10]  
Falser, Bandtlow, Haus, Et al., Detection of pseudorabies virus DNA in the inner ear of intranasally infected BALB/c mice with nucleic acid hybridization in situ, J Virol, 57, pp. 335-339, (1986)