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GROWTH FAILURE, SOMATOMEDIN AND GROWTH-HORMONE LEVELS IN JUVENILE DIABETES-MELLITUS - PILOT-STUDY

被引：16
作者：
NASH, H
机构：
[1] Adelaide Children's Hospital, South Australia
来源：
AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE | 1979年 / 9卷 / 03期
关键词：
D O I：
10.1111/j.1445-5994.1979.tb04131.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Summary: Growth hormone (hGH) responsiveness to exercise and Somatomedin C (SmC) activity were measured in ten children with insulin‐deficient diabetes mellitus. Four of the ten children showed a significant degree of growth retardation. Normal SmC activity was found in association with elevated hGH levels. The hypothesis that growth‐retarded diabetics have a failure of Sm production despite high hGH levels (analogous to malnutrition and Laron dwarfism) was not substantiated by this study. Chronic deficiency of insulin, itself a somatomedin, may play a major role in diabetic growth failure. Copyright © 1979, Wiley Blackwell. All rights reserved
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页码：245 / 249
页数：5
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