CHYMOTRYPSIN TREATMENT INCREASES THE ACTIVITY OF CLOSTRIDIUM-PERFRINGENS ENTEROTOXIN

被引：14

作者：

GRANUM, PE ^{[1
]}

RICHARDSON, M ^{[1
]}

机构：

[1] UNIV DURHAM,DEPT BIOL SCI,DURHAM DH1 3HP,ENGLAND

来源：

TOXICON | 1991年 / 29卷 / 07期

关键词：

D O I：

10.1016/0041-0101(91)90227-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chymotrypsin treatment of the enterotoxin from Clostridium perfringens results in the loss of 36 amino acids from the N-terminus and 3 amino acids from the C-terminus. This processing results in a 3.2 fold increase in activity on Vero cells, which is close to what had been found for trypsin treatment following the loss of 25 amino acids from the N-terminus.

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页码：898 / 900

页数：3

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