COMPLEMENT ACTIVATION DURING LIVER-TRANSPLANTATION

被引：32

作者：

TOMASDOTTIR, H

HENRIKSSON, BA

BENGTSON, JP

BENGTSSON, A

STENQVIST, O

PERSSON, H

机构：

[1] SAHLGRENS UNIV HOSP,DEPT ANAESTHESIOL & INTENS CARE,S-41345 GOTHENBURG,SWEDEN

[2] SAHLGRENS UNIV HOSP,DEPT SURG,S-41345 GOTHENBURG,SWEDEN

来源：

TRANSPLANTATION | 1993年 / 55卷 / 04期

关键词：

D O I：

10.1097/00007890-199304000-00022

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Twelve patients with end-stage liver disease undergoing liver transplantation were studied regarding complement activation and formation of anaphylatoxins (C3a and C5a) and terminal C5b-9 complement complexes (TCC) after reperfusion of the grafted liver. Blood samples for complement variables (C1INH, C3, C4, C5, C3a, C5a, and TCC) were drawn preoperatively, before the anhepatic phase, 1 min before, and 2, 15, and 60 min after the start of reperfusion of the grafted liver. Activation of complement was observed during t,he operation. The C1INH, C3, C4, and C5 plasma concentrations decreased during the entire operation while the anaphylatoxin C3a and the terminal C5b-9 complement complex increased after the reperfusion of the grafted liver. Activation of complement with the formation of biologically active substances like anaphylatoxins and terminal C5b-9 complement complexes may be one explanation for circulatory complications often seen in patients undergoing orthotopic liver transplantation.

引用

页码：799 / 802

页数：4

共 27 条

[1] COMPLEMENT AND ANAPHYLATOXIN RESPONSES TO CROSS-CLAMPING OF THE AORTA - STUDIES DURING GENERAL-ANESTHESIA WITH OR WITHOUT EXTRADURAL BLOCKADE [J].