IMMUNE-RESPONSE TO TUMOR-ANTIGENS IN A PATIENT WITH COLORECTAL-CANCER AFTER IMMUNIZATION WITH ANTIIDIOTYPE ANTIBODY

被引：26

作者：

SAMONIGG, H

WILDERSTRUSCHNIG, M

LOIBNER, H

PLOT, R

ROT, A

KUSS, I

WERNER, G

STOGER, H

WRANN, M

HERLYN, D

KOPROWSKI, H

机构：

[1] SANDOZ GMBH,A-1235 VIENNA,AUSTRIA

[2] WISTAR INST,PHILADELPHIA,PA 19104

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1992年 / 65卷 / 03期

关键词：

D O I：

10.1016/0090-1229(92)90157-J

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An active vaccination protocol was performed on one patient with colon carcinoma as a pilot to a prospective randomized double-blind clinical trial with the vaccine SDZ SCV 106. This vaccine is an anti-idiotype goat antibody to the monoclonal antibody 17-1A, which is directed against the tumor antigen 17-1A. To study the effect of the therapy on the immune reactivity, several tests were performed to detect anti-tumor antibodies in the serum as well as in eluates of metastatic tissue. Furthermore metastases removed from the lung were examined by immunohistochemistry. The results suggest that the humoral and cellular immune reactivity against the tumor are enhanced. © 1992.

引用

页码：271 / 277

页数：7

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