EXISTENCE OF A MOLECULAR RULER IN PROTEASOMES SUGGESTED BY ANALYSIS OF DEGRADATION PRODUCTS

被引：153

作者：

WENZEL, T ^{[1
]}

ECKERSKORN, C ^{[1
]}

LOTTSPEICH, F ^{[1
]}

BAUMEISTER, W ^{[1
]}

机构：

[1] MAX PLANCK INST BIOCHEM,D-82152 MARTINSRIED,GERMANY

来源：

FEBS LETTERS | 1994年 / 349卷 / 02期

关键词：

PROTEASOME; MOLECULAR RULER; THERMOPLASMA ACIDOPHILUM; PROTEOLYTIC DEGRADATION; INSULIN B-CHAIN; HEMOGLOBIN;

D O I：

10.1016/0014-5793(94)00665-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analysis of the degradation products from two proteins, the insulin B-chain and human hemoglobin, generated by archaebacterial Thermoplasma acidophilum 20 S proteasomes, revealed an unexpectedly broad specificity. In spite of the vast number of different peptides found, they fell into a rather narrow size range. This suggests that a molecular ruler exists which determines the length of the cleavage products.

引用

页码：205 / 209

页数：5

共 31 条

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