HYDROPHILIC-HYDROPHOBIC BINARY-SYSTEMS OF POLY(2-HYDROXYETHYL METHACRYLATE) AND POLYCAPROLACTONE .2. DEGRADATION

被引：6

作者：

ESCHBACH, FO ^{[1
]}

HUANG, SJ ^{[1
]}

CAMERON, JA ^{[1
]}

机构：

[1] UNIV CONNECTICUT,DEPT MOLEC & CELL BIOL,STORRS,CT 06269

来源：

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 1994年 / 9卷 / 02期

关键词：

D O I：

10.1177/088391159400900206

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels can be mechanically reinforced by the incorporation of a hydrophobic biodegradable polyester, polycaprolactone (PCL). The influence of PHEMA on the selective degradability of PCL in the modified hydrogels was investigated by hydrolysis, biodegradation and chemical degradation. The swelling of the PHEMA component in hydrophilic reagents provided hydrolytic exposure to PCL domains. In hydrophobic reagents, the PHEMA component acted as a barrier that retarded the diffusion of hydrophobic acid or base into the network.

引用

页码：210 / 221

页数：12

共 28 条

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