CORRELATION OF PAROTID SALIVA AND BLOOD ETHANOL CONCENTRATIONS

被引:15
作者
DIGREGORIO, GJ [1 ]
PIRAINO, AJ [1 ]
RUCH, E [1 ]
机构
[1] HAHNEMANN MED COLL & HOSP,DEPT PHARMACOL,PHILADELPHIA,PA 19102
关键词
D O I
10.1016/0376-8716(78)90034-0
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
This paper is devoted to the detection and quantitation of blood and parotid saliva ethanol in both human subjects and rats. The human ethanol saliva-plasma ratio has been determined to be 1.04 utilizing a collection technique which is non-invasive and easily performed. The rat ethanol saliva-plasma ratio has been found to be 1.21 with a direct cannulation technique of the parotid duct. Differences between the human and rat ratios have been attributed to the method of salivary gland stimulation. The human parotid gland was stimulated by a reflex action of an organe-flavored lozenge, whereas the rat parotid gland was stimulated by a direct infusion of pilocarpine. The results indicate that the rat parotid secretion of ethanol is very similar to the human secretions, and the rat could possibly be utilized as an animal model for future alcohol salivary studies. © 1978.
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页码:43 / 50
页数:8
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