EVOLUTIONARY AND GENETIC-IMPLICATIONS OF SEQUENCE VARIATION IN 2 NONALLELIC HLA-DR BETA-CHAIN CDNA SEQUENCES

被引：20

作者：

CURTSINGER, JM ^{[1
]}

HILDEN, JM ^{[1
]}

CAIRNS, JS ^{[1
]}

BACH, FH ^{[1
]}

机构：

[1] UNIV MINNESOTA, IMMUNOBIOL RES CTR, DEPT LAB MED & PATHOL, BOX 724, MAYO BLDG, MINNEAPOLIS, MN 55455 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1987年 / 84卷 / 01期

关键词：

D O I：

10.1073/pnas.84.1.209

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Most HLA haplotypes carry two expressed DR .beta.-chain genes; in the DR4 haplotype, the polymorphic locus has been called DR .beta.1 and the apparently nonpolymorphic locus has been called DR .beta.2. We have isolated nearly full-length DR .beta.-chain cDNA clones representing each of these two loci from a cell line homozygous for DR4 and Dw4. The clones have been sequenced and the sequences compared with published DR .beta. cDNA sequenced derived from other haplotypes. A comparison of our sequences with other published cDNA sequences did not allow assignment of these other sequences to either the .beta.1 or .beta.2 locus. Comparison of our DR4 .beta.1 sequence with DR .beta.1 sequences isolated from other DR4-positive cells suggests that the alleles of DR4 .beta.1 may have recently diverged from a common ancestor. The apparent lack of polymorphism of DR .beta.2 may in part be a reflection of this recent divergence.

引用

页码：209 / 213

页数：5

共 31 条

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