INDUSTRIAL-PRODUCTION OF MONOCLONAL-ANTIBODIES AND THERAPEUTIC PROTEINS BY DIALYSIS FERMENTATION

被引：23

作者：

COMER, MJ

KEARNS, MJ

WAHL, J

MUNSTER, M

LORENZ, T

SZPERALSKI, B

KOCH, S

BEHRENDT, U

BRUNNER, H

机构：

[1] Research Centre Penzberg, Boehringer Mannheim GmbH, Penzberg, 8122, Nonnenwald

来源：

CYTOTECHNOLOGY | 1990年 / 3卷 / 03期

关键词：

large-scale cultivation; monoclonal antibodies; therapeutic proteins;

D O I：

10.1007/BF00365493

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel and powerful fermentation method is reported for the large-scale growth of mammalian cells and their secreted products. The system described illustrates many of the advantages of conventional batch fermentation processes but in addition has been shown to yield cell densities in excess of 1×107 cells/ml with concomitant increase in product concentration. © 1990 Kluwer Academic Publishers.

引用

页码：295 / 299

页数：5

共 9 条

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