EFFECT OF DIFFERENT DOSES OF 3-METHYLCHOLANTHRENE ON THE LOCALIZATION OF THE 3-METHYLCHOLANTHRENE-INDUCIBLE ISOENZYMES OF CYTOCHROME-P450 WITHIN THE CENTRILOBULAR AND PERIPORTAL ZONES OF THE RAT-LIVER

被引：18

作者：

VANSLIEDREGT, A ^{[1
]}

VANBEZOOIJEN, CFA ^{[1
]}

机构：

[1] TNO,INST EXPTL GERONTOL,2280 HV RIJSWIJK,NETHERLANDS

来源：

BIOCHEMICAL PHARMACOLOGY | 1990年 / 39卷 / 11期

关键词：

D O I：

10.1016/0006-2952(90)90114-Z

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Irnmunohistochemical staining techniques were used to investigate the localization of the 3-methylcholanthrene inducible isoenzymes (P450 IA1 and IA2) in the rat liver. The rats were induced with different doses of 3-methylcholanthrene, ranging from 2.5 to 25mg/kg body weight. A heterogeneous induction pattern was observed with induction doses of 2.5; 5; 7.5 and 10 mg/kg body weight with the highest concentration of the isoenzymes around the central vein. With a dose of 25 mg/kg body weight, a homogeneous pattern was found. Induction with a dose of 15 mg/kg body weight resulted in an intermediate situation. © 1990.

引用

页码：1703 / 1708

页数：6

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