ADDITIONAL PEDIGREE SUPPORTING THE FREQUENT ORIGIN OF XXYY FROM CONSECUTIVE MEIOTIC NONDISJUNCTION IN PATERNAL GAMETOGENESIS

被引：11

作者：

RINALDI, A

ARCHIDIACONO, N

ROCCHI, M

FILIPPI, G

机构：

[1] SLOAN KETTERING INST CANC RES,NEW YORK,NY 10021

[2] UNIV ROME,CNR,CTR GENET EVOLUZ,I-00100 ROME,ITALY

[3] UNIV TRIESTE,IST GENET MED,I-34127 TRIESTE,ITALY

[4] IST INFANZIA TRIESTE,TRIESTE,ITALY

来源：

JOURNAL OF MEDICAL GENETICS | 1979年 / 16卷 / 03期

关键词：

D O I：

10.1136/jmg.16.3.225

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A 48,XXYY Sardinian patient, born to a 46,XX mother heterozygous for the Gd Mediterranean mutant, and to a 46,XY father hemizygous for the same mutant, was found to have a mosaic distribution of G6PD(+) and G6PD(-) peripheral red blood cells. The most likely interpretation of this finding is that the propositus is an additional example of an XXYY zygote derived from a consecutive meiotic non-disjunction during paternal gametogenesis.

引用

页码：225 / 226

页数：2

共 5 条

[1] SUCCESSIVE NON-DISJUNCTION AT 1ST AND 2ND MEIOTIC DIVISION OF SPERMATOGENESIS - EVIDENCE OF CHROMOSOMES AND XG [J].