ORGANIC SHIFT-REAGENTS FOR THE NMR ANALYSIS OF CYCLODEXTRINS

被引：22

作者：

DJEDAINI, F ^{[1
]}

PERLY, B ^{[1
]}

机构：

[1] CENS,DPHG SCM,F-91191 GIF SUR YVETTE,FRANCE

来源：

JOURNAL OF MOLECULAR STRUCTURE | 1990年 / 239卷

关键词：

D O I：

10.1016/0022-2860(90)80209-3

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The analysis of proton NMR spectra of natural or chemically modified cyclodextrins can be greatly simplified by using 'organic shift reagents'. When incorporated in the cyclodextrin internal cavity, they induce shifts of the NMR lines which may be large enough to transform the strongly coupled spectra into first order systems amenable to direct analysis. These observations are based on studies of the inclusion of hydrophobic drugs into these host molecules. © 1990.

引用

页码：161 / 166

页数：6

共 6 条

[1]

DJEDAINI F, 1990, IN PRESS J PHARM SCI, V79

[2] INCLUSION COMPLEXATIONS OF INDOMETHACIN AND ITS RELATED-COMPOUNDS WITH CYCLODEXTRINS IN AQUEOUS-SOLUTION [J].

HOSHINO, T ;

TAGAWA, Y ;

HIRAYAMA, F ;

OTAGIRI, M ;

UEKAMA, K .

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1982, 102 (12) :1184-1190

[3] CYCLODEXTRIN INCLUSION-COMPOUNDS IN RESEARCH AND INDUSTRY [J].

SAENGER, W .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1980, 19 (05) :344-362

[4]

SZEJTLI J, 1982, PHARMAZIE, V36, P694

[5]

UEKAMA K, 1982, INT J PHARMACEUT, V10, P1

[6] INCLUSION OF SPIRONOLACTONE IN CYCLOMALTOHEPTAOSE - A GUEST AFFECTED BY THE HOSPITALITY OF THE HOST [J].

WOUESSIDJEWE, D ;

CRASSOUS, A ;

DUCHENE, D ;

COLEMAN, A ;

RYSANEK, N ;

TSOUCARIS, G ;

PERLY, B ;

DJEDAINI, F .

CARBOHYDRATE RESEARCH, 1989, 192 :313-322

← 1 →