A NEW RURAL FOCUS OF CUTANEOUS LEISHMANIASIS CAUSED BY LEISHMANIA-TROPICA IN KENYA

被引：25

作者：

MEBRAHTU, YB ^{[1
]}

LAWYER, PG ^{[1
]}

NGUMBI, PM ^{[1
]}

KIRIGI, G ^{[1
]}

MBUGUA, J ^{[1
]}

GACHIHI, G ^{[1
]}

WASUNNA, K ^{[1
]}

PAMBA, H ^{[1
]}

SHERWOOD, JA ^{[1
]}

KOECH, DK ^{[1
]}

ROBERTS, CR ^{[1
]}

机构：

[1] UNIV NAIROBI, FAC MED, NAIROBI, KENYA

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1992年 / 86卷 / 04期

关键词：

D O I：

10.1016/0035-9203(92)90230-A

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We have identified a new rural focus of cutaneous leishmaniasis caused by Leishmania tropica in Muruku sublocation, Salama location, Laikipia district, Rift Valley province, Kenya. Based on a few available case histories, previous reports of L. tropica in Kenya indicated a tentative geographical distribution. Recently 6 indigenous Kenyans from the new focus, who had never travelled outside Kenya, developed cutaneous lesions on the face and/or extremities found to contain Leishmania by culture and smear. Most of the patients manifested the typical 'urban' dry sore which grew slowly into a nodule measuring 2 x 1 cm to 9.5 x 3 cm, and after some months formed a central crust surrounded by small satellite papules. After treatment with Pentostam(R) (sodium stibogluconate), about 40% of the sores failed to heal completely, either scarring centrally with fulminating papules at the edges and spreading peripherally, or healing but then recrudescing at the edge of the scar. Stationary-phase promastigotes from culture isolates were analysed by cellulose acetate electrophoresis. Isoenzyme profiles of 6 isolates were compared with those of World Health Organization reference strains using 12 enzyme loci; they were indistinguishable from those of 2 L. tropica reference strains. All 6 case sites lay within a radius of 4 km. Several other suspected cases from the same area are being investigated.

引用

页码：381 / 387

页数：7

共 33 条

[1] NUMERICAL TAXONOMY OF SOME OLD-WORLD LEISHMANIA SPECIES [J].