INTIMAL THICKENING OF THE CORONARY-ARTERIES IN INFANTS IN RELATION TO FAMILY HISTORY OF CORONARY-ARTERY DISEASE

被引:52
作者
KAPRIO, J
NORIO, R
PESONEN, E
SARNA, S
机构
[1] FINNISH POPULAT & FAMILY WELFARE FEDERAT,DEPT MED GENET,HELSINKI,FINLAND
[2] UNIV HELSINKI,CHILDRENS HOSP,SF-00100 HELSINKI 10,FINLAND
关键词
MORPHOGENESIS; ARTERIOSCLEROSIS; GENETICS;
D O I
10.1161/01.CIR.87.6.1960
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. Intimal thickenings of the coronary arteries of newborn children are composed mainly of smooth muscle cell proliferations. To investigate whether thickening of the intima in infants is associated with a family history of coronary artery disease (CAD), we studied the relation of coronary death of grandparents to intimal thickening of 136 infants. Methods and Results. The length of internal elastic lamina of the artery and the areas of arterial layers in cross section were measured, and the arteries were transformed to idealized round circles. Intimal thickening was assessed as the degree of luminal narrowing (ratio of intimal area to the area on the luminal side of the arterial media). Among 136 infants, luminal narrowing varied between 0% and 58%. CAD deaths accounted for 108 of the total 281 deaths among the grandparents of the infants. Family history of CAD (defined as at least one CAD death among the four grandparents) was positive for 77 infants. Family history of CAD was, significantly more common in the infants with luminal narrowing of both the left and right coronary arteries compared with the infants with no narrowing in at least one artery (odds ratio adjusted for sex, infection status, and age of infant, 5.69; 95% confidence interval, 1.46-22.2). After adjustment for sex and age, infants with both a positive family history and presence of infection had an increased degree of luminal narrowing compared with infants with a negative family history and no infection. Conclusions. The association of coronary artery intimal thickening in infancy with family history of CAD suggests that intimal thickening is a morphological manifestation of predisposition to CAD.
引用
收藏
页码:1960 / 1968
页数:9
相关论文
共 38 条
[1]   CORONARY ARTERIAL-WALL AND ATHEROSCLEROSIS IN YOUTH (1-20 YEARS) - A HISTOLOGIC-STUDY IN A NORTHERN ITALIAN POPULATION [J].
ANGELINI, A ;
THIENE, G ;
FRESCURA, C ;
BAROLDI, G .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 1990, 28 (03) :361-370
[2]  
[Anonymous], 1980, SCIENCE, DOI DOI 10.1126/SCIENCE.208.4448.1138
[3]  
BECKER A, 1984, ACTA MED SCAND, V694, P69
[4]   THE PREDILECTION OF ATHEROSCLEROSIS FOR THE CORONARY ARTERIES [J].
DOCK, W .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1946, 131 (11) :875-878
[5]   CORONARY DISEASE AMONG UNITED-STATES SOLDIERS KILLED IN ACTION IN KOREA [J].
ENOS, WF ;
HOLMES, RH ;
BEYER, J .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1953, 152 (12) :1090-1093
[6]  
FANGMAN RJ, 1947, AM J PATHOL, V23, P901
[7]   MECHANISMS OF DISEASE - THE PATHOGENESIS OF CORONARY-ARTERY DISEASE AND THE ACUTE CORONARY SYNDROMES .1. [J].
FUSTER, V ;
BADIMON, L ;
BADIMON, JJ ;
CHESEBRO, JH .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (04) :242-250
[8]   LOCALIZATION OF ATHEROSCLEROTIC LESIONS IN THE BIFURCATION OF THE MAIN LEFT CORONARY-ARTERY [J].
GROTTUM, P ;
SVINDLAND, A ;
WALLOE, L .
ATHEROSCLEROSIS, 1983, 47 (01) :55-62
[9]   APOLIPOPROTEIN-E POLYMORPHISMS AFFECT ATHEROSCLEROSIS IN YOUNG MALES [J].
HIXSON, JE .
ARTERIOSCLEROSIS AND THROMBOSIS, 1991, 11 (05) :1237-1244
[10]  
JAFFE D, 1971, ACTA PAEDIATR SC S, V219, P1