NORMALIZATION OF ENHANCED NEUTROPHIL CYTOSOLIC-FREE CALCIUM OF HEMODIALYSIS-PATIENTS BY 1,25-DIHYDROXYVITAMIN D-3 OR CALCIUM-CHANNEL BLOCKER

被引：20

作者：

HAAGWEBER, M ^{[1
]}

MAI, B ^{[1
]}

HORL, WH ^{[1
]}

机构：

[1] UNIV VIENNA, MED KLIN 3, DEPT MED, DIV NEPHROL, A-1090 VIENNA, AUSTRIA

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 1993年 / 13卷 / 06期

关键词：

HEMODIALYSIS; NEUTROPHILS; CYTOSOLIC CALCIUM; CALCIUM CHANNEL BLOCKER; 1,25-DIHYDROXYVITAMIN D3; GLUCOSE UPTAKE;

D O I：

10.1159/000168665

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Patients undergoing regular hemodialysis treatment display elevated intracellular free calcium and impaired glucose uptake in polymorphonuclear leukocytes (PMNLs) in the presence of enhanced serum parathyroid hormone (PTH) levels. Normalization of intracellular calcium can be achieved by different therapeutic interventions acting by different mechanisms. Effective oral 1,25-dihydroxyvitamin D-3 therapy (0.5-1.0 mu g/day) normalizes PMNL cytosolic calcium via suppression of PTH levels. Hemodialysis patients treated orally with the calcium channel blocker nitrendipine (20-40 mg/day) normalizes calcium without affecting serum PTH levels. Both therapeutic interventions improved glucose uptake and displayed no synergistic effect.

引用

页码：467 / 472

页数：6

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