APOLIPOPROTEIN-E POLYMORPHISM, SERUM-LIPIDS, MYOCARDIAL-INFARCTION AND SEVERITY OF ANGIOGRAPHICALLY VERIFIED CORONARY-ARTERY DISEASE IN MEN SIND WOMEN

被引:109
作者
LEHTINEN, S
LEHTIMAKI, T
SISTO, T
SALENIUS, JP
NIKKILA, M
JOKELA, H
KOIVULA, T
EBELING, F
EHNHOLM, C
机构
[1] TAMPERE UNIV HOSP,DEPT CLIN CHEM,SF-33521 TAMPERE,FINLAND
[2] TAMPERE UNIV HOSP,DEPT SURG,SF-33521 TAMPERE,FINLAND
[3] FINNISH RED CROSS & BLOOD TRANSFUS SERV,BLOOD TRANSFUS SERV,HELSINKI,FINLAND
[4] NATL PUBL HLTH INST,HELSINKI,FINLAND
[5] CENT HOSP KANTA HAME,DEPT INTERNAL MED,HAMEENLINNA,FINLAND
关键词
APOLIPOPROTEIN E PHENOTYPES; SERUM CHOLESTEROL; CORONARY ARTERY DISEASE;
D O I
10.1016/0021-9150(94)05469-Y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In several populations, the apolipoprotein E (ape E) allele epsilon 4 is associated with high concentration of plasma total and low density lipoprotein (LDL)-cholesterol and coronary artery disease (CAD). We determined the apo E phenotypes of 309 patients with angiographically verified CAD and 38 patients without CAD by isoelectric focusing and Western blotting. In men with CAD, the plasma total and LDL-cholesterol increased according to apo E phenotype in the following order: E3/2 < E3/3 < E4/3 < E4/4 (P = 0.03 for total cholesterol, P = 0.007 for LDL-cholesterol), In women, there was a similar trend(P = 0.22 for total cholesterol, P = 0.15 for LDL-cholesterol). The relative frequency of men with three vessel CAD increased (P = 0.43) together with LDL-cholesterol levels (P = 0.05) according to apo E phenotype E3/2, E3/3, E4/3, E4/4. Total and LDL-cholesterol levels were higher in patients with three vessel CAD than in patients with less serious types of CAD (P = 0.02 for total cholesterol, P = 0.007 for LDL-cholesterol), The relative frequency of patients with myocardial infarction increased according to apo E phenotype (P = 0.51). Both in men and women, there were no differences between apo E phenotypes in age at occurrence of the first myocardial infarction. The apo E allele frequencies of patients with CAD vs. without CAD were 2.3% vs. 1.3% for epsilon 2, 79.0% vs. 76.3% for epsilon 3 and 18.7% vs. 22.4% for epsilon 4. There were no statistically significant differences in apo E allele or phenotype Frequencies between patients with CAD and without CAD or between patients with CAD and the general Finnish population. Our results support previous studies in suggesting that the apo E allele epsilon 4 is a risk factor for atherosclerosis, which affects plasma total and LDL-cholesterol. In addition, our results suggest that the apo E allele determines the severity of CAD.
引用
收藏
页码:83 / 91
页数:9
相关论文
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