POLYELECTROLYTE COMPLEX CONSISTING OF CARBOXYMETHYLDEXTRAN, SODIUM DEXTRANSULFATE, AND CHITOSAN

Water-insolubule precipitates (PEC) were prepared by mixing the mixture of carboxymethyldextran solution (CMD) and sodium dextransulfate solution (DS) with chitosan at different hydrogen ion concentrations and in different order of mixing, The mole ratios of S/N in the polyelectrolyte complexes (PEC) thus prepared were estimated to be 0.42~0.77, and also the content of CMD in PEC formed at high hydrogen ion concentration was found to be less than that formed at low hydrogen ion concentration by IR spectroscopic studies. It was found that the hydrogen ion concentration and the order of mixing showed remarkable effect on the composition of PFC produced. On the basis of the studies of IR spectra, elemental analyses, and color ractiori with-Tolui-dine Blue, the structure of PEC prepared was found to differ with each othex according to the preparation method. It seemed that the degree of dissociation and the conformation of CMD, DS, and chitosan changed with hydrogen ion concentration, and that a different neutralization reaction occurred in terms of different order of mixing., In addition, blood tests were performed for the PEC by Imai's method to evaluate its antithrombogenicity. © 1979, The Chemical Society of Japan. All rights reserved.