D-METHIONINE UTILIZATION DURING PARENTERAL NUTRITION IN ADULT-RATS

被引:18
作者
CHO, ES
STEGINK, LD
机构
[1] UNIV IOWA,DEPT PEDIAT,IOWA CITY,IA 52242
[2] UNIV IOWA,DEPT BIOCHEM,IOWA CITY,IA 52242
关键词
D O I
10.1093/jn/109.6.1086
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
D-Methionine, present in some parenteral solutions, is poorly utilized by man. To evaluate some of the factors affecting utilization, methionine isomer excretion was measured in rats treated with two different parenteral regimens: total parenteral nutrition and protein sparing therapy. Within each regimen, nutrient solutions differing only in methionine isomer composition were compared. Eight rats on the total parenteral nutrition regimen were infused with a 33% glucose - 2.8% amino acid solution at a rate providing 100% of energy requirement. Four rats received the parenteral solution containing L-methionine, and four the solution containing DL-methionine. Eight additional rats on a protein sparing regimen were infused with an amino acid solution (8.5%) at a rate to provide 25% of energy requirement. Four rats were infused with a solution containing L-methionine, and four with a solution containing DL-methionine. Total methionine content of livers was not affected by differences in methionine isomer. Infusion of the solution containing DL-methionine significantly increased plasma methionine levels during protein sparing therapy, with the increase representing accumulation of the D-isomer. Rats receiving protein sparing therapy had significantly higher liver methionine levels than rats receiving total parenteral nutrition. Although rats infused with the solution containing DL-methionine had elevated plasma methionine levels during protein sparing therapy, urinary methionine losses were small, as were losses of methionine sulfoxide and α-keto-γ-methiolbutyrate. In contrast to humans, adult rats utilized more than 99% of parenterally administered D- or L-methionine.
引用
收藏
页码:1086 / 1093
页数:8
相关论文
共 36 条
[1]  
BANSI HW, 1970, PARENTERAL NUTRITION, P218
[2]   TOXICITIES OF METHIONINE AND OTHER AMINO-ACIDS [J].
BENEVENGA, NJ .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1974, 22 (01) :2-9
[3]  
BENEVENGA NJ, 1976, J NUTR, V106, P1714, DOI 10.1093/jn/106.12.1715
[4]   PHYSIOLOGY OF THE D-AMINO ACIDS [J].
BERG, CP .
PHYSIOLOGICAL REVIEWS, 1953, 33 (02) :145-189
[5]  
Berg CP, 1959, PROTEIN AMINO ACID N, P57, DOI [10.1016/B978-0-12-395683-5.50008-0, DOI 10.1016/B978-0-12-395683-5.50008-0]
[6]   PERIPHERAL INTRAVENOUS FEEDING WITH ISOTONIC AMINO-ACID SOLUTIONS [J].
BLACKBURN, GL ;
FLATT, JP ;
CLOWES, GHA ;
ODONNELL, TE .
AMERICAN JOURNAL OF SURGERY, 1973, 125 (04) :447-454
[7]  
BLACKBURN GL, 1973, ANN SURG, V177, P588, DOI 10.1097/00000658-197305000-00012
[8]  
BROWN JH, 1948, P SOC EXP BIOL MED, V69, P196, DOI 10.3181/00379727-69-16666
[9]  
Cahill WM, 1942, J BIOL CHEM, V145, P201
[10]   EVIDENCE FOR S-ADENOSYLMETHIONINE INDEPENDENT CATABOLISM OF METHIONINE IN RAT [J].
CASE, GL ;
BENEVENGA, NJ .
JOURNAL OF NUTRITION, 1976, 106 (12) :1721-1736