INHIBITION OF BONE-MINERAL LOSS DURING LACTATION BY CL2MBP

被引:9
作者
BROMMAGE, R [1 ]
BAXTER, DC [1 ]
机构
[1] CHICAGO COLL OSTEOPATH MED,DEPT PHYSIOL,DOWNERS GROVE,IL
关键词
Bisphosphanates; Bone resorption; Lactation; Vitamin D;
D O I
10.1007/BF02555983
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Pregnant rats were injected subcutaneously with either saline or the bisphosphonate Cl2MBP (dichloromethylenebisphosphonic acid) at a daily dose of 15 mg P/kg body weight on days 1 through 16 of gestation. Cl2MBP treatment did not influence maternal body weight nor the number of pups born. When analyzed 1 day after birth, pups from Cl2MBP-treated rats had a normal body weight but a 10% reduction in carcass calcium (Ca) content. The Cl2MBP injections were resumed on day 1 postpartum and led to a 10% reduction in pup body weight gain and carcass Ca content at 16 days of age. In saline-injected rats, lactation resulted in slight hypocalcemia, greatly elevated serum levels of 1,25(OH)2D3, and loss of bone mineral, as indicated by a reduction in femur ash weight. In nonlactating rats, Cl2MBP treatment produced slight hypercalcemia but had no effect on serum 1,25(OH)2D3 levels or bone mineral content. Compared to lactating rats receiving saline, Cl2MBP-treated lactating rats were more hypocalcemic and had higher serum 1,25(OH)2D3 levels. However, the lactation-induced loss of bone mineral was completely inhibited by Cl2MBP treatment. © 1990 Springer-Verlag New York Inc.
引用
收藏
页码:169 / 172
页数:4
相关论文
共 18 条
[1]   PARATHYROID HORMONE-INDEPENDENT REGULATION OF 1,25(OH)2D IN RESPONSE TO INHIBITION OF BONE-RESORPTION [J].
BONJOUR, JP ;
TRECHSEL, U ;
TAYLOR, CM ;
FLEISCH, H .
AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 254 (03) :E260-E264
[2]   SELF-SELECTION OF A HIGH CALCIUM DIET BY VITAMIN-D DEFICIENT LACTATING RATS INCREASES FOOD-CONSUMPTION AND MILK-PRODUCTION [J].
BROMMAGE, R ;
DELUCA, HF .
JOURNAL OF NUTRITION, 1984, 114 (08) :1377-1385
[3]   MEASUREMENT OF CALCIUM AND PHOSPHORUS FLUXES DURING LACTATION IN THE RAT [J].
BROMMAGE, R .
JOURNAL OF NUTRITION, 1989, 119 (03) :428-438
[4]   REGULATION OF BONE-MINERAL LOSS DURING LACTATION [J].
BROMMAGE, R ;
DELUCA, HF .
AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 248 (02) :E182-E187
[5]  
BROMMAGE R, 1988, J BONE MINER RES S1, V3, pS156
[6]   HUMAN PARATHYROID-HORMONE 1-34-MEDIATED HYPERCALCEMIA IN A RAT MODEL, AND ITS INHIBITION BY DICHLOROMETHANE DIPHOSPHONATE [J].
DOPPELT, SH ;
NEER, RM ;
POTTS, JT .
CALCIFIED TISSUE INTERNATIONAL, 1981, 33 (06) :649-654
[7]   SKELETAL CHANGES DURING PREGNANCY AND LACTATION IN THE RAT - EFFECT OF DIFFERENT LEVELS OF DIETARY CALCIUM [J].
ELLINGER, GM ;
DUCKWORTH, J ;
DALGARNO, AC ;
QUENOUILLE, MH .
BRITISH JOURNAL OF NUTRITION, 1952, 6 (03) :235-253
[8]  
Fleisch H, 1983, BONE MINERAL RES ANN, P319
[9]  
GARNER SC, 1987, J BONE MINER RES, V2, P347
[10]   CALCIUM-TRANSPORT IN SMALL-INTESTINE DURING PREGNANCY AND LACTATION [J].
HALLORAN, BP ;
DELUCA, HF .
AMERICAN JOURNAL OF PHYSIOLOGY, 1980, 239 (01) :E64-E68