学术探索
学术期刊
新闻热点
数据分析
智能评审

EFFECTS OF 2,3,7,8-TETRACHLORODIBENZOFURAN (TCDF) ON THE IMMUNE SYSTEM IN GUINEA-PIGS

被引：14
作者：
LUSTER, MI
FAITH, RE
LAWSON, LD
机构：
[1] National Institutes of Health National, Institute of Environmental Health Sciences, Research Triangle Park, NC
来源：
DRUG AND CHEMICAL TOXICOLOGY | 1979年 / 2卷 / 1-2期
关键词：
D O I：
10.3109/01480547908993181
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The effects of TCDF exposure on the immune system were investigated in Hartley guinea pigs. TCDF was administered by gavage at doses of 0.05, 0.17, 0.5 or 1.0 ug/kg body weight once weekly for six weeks. Thymus/body weight ratios were suppressed in the higher dosage groups. Parameters of cell-mediated and humoral immune function were investigated. TCDF modestly suppressed cell-mediated immune function and had slight effects on humoral-mediated functions. TCDF immunosuppression appears similar to that induced following exposure to TCDD. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
引用
收藏
页码：49 / 60
页数：12
相关论文
共 24 条
  • [1] GLUTARALDEHYDE CYANURIC CHLORIDE AND TETRAAZOTIZED O-DIANISISDINE AS COUPLING REAGENTS IN PASSIVE HEMAGGLUTINATION TEST
    AVRAMEAS, S
    TAUDOU, B
    CHUILON, S
    [J]. IMMUNOCHEMISTRY, 1969, 6 (01): : 67 - &
  • [2] IDENTIFICATION OF CHLORINATED DIBENZOFURANS IN AMERICAN POLYCHLORINATED BIPHENYLS
    BOWES, GW
    MULVIHILL, MJ
    SIMONEIT, BRT
    BURLINGAME, AL
    RISEBROUGH, RW
    [J]. NATURE, 1975, 256 (5515) : 305 - 307
  • [3] BRAENDSTRUP O, 1975, ACTA PATH MICRO IM C, V83, P52
  • [4] CHEMICAL SEPARATION OF HELPER CELL-FUNCTION AND DELAYED-HYPERSENSITIVITY RESPONSES
    FAITH, RE
    LUSTER, MI
    MOORE, JA
    [J]. CELLULAR IMMUNOLOGY, 1978, 40 (02) : 275 - 284
  • [5] IMPAIRMENT OF THYMUS-DEPENDENT IMMUNE FUNCTIONS BY EXPOSURE OF DEVELOPING IMMUNE SYSTEM TO 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN (TCDD)
    FAITH, RE
    MOORE, JA
    [J]. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1977, 3 (03): : 451 - 464
  • [6] GUPTA B N, 1973, Environmental Health Perspectives, V5, P125
  • [7] HOLLANDER M, 1973, NONPARAMETRIC STATIS
  • [8] KURATSUNE M, 1975, NOV NATL C PCBS CHIC
  • [9] MEASUREMENT OF TUBERCULIN HYPERSENSITIVITY IN RATS
    LEFFORD, MJ
    [J]. INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1974, 47 (04): : 570 - 585
  • [10] LOOSE LD, 1977, TOXICOL APPL PHARM, V41, P203
123