A POU-DOMAIN TRANSCRIPTION FACTOR IN EARLY STEM-CELLS AND GERM-CELLS OF THE MAMMALIAN EMBRYO

被引：763

作者：

ROSNER, MH

VIGANO, MA

OZATO, K

TIMMONS, PM

POIRIER, F

RIGBY, PWJ

STAUDT, LM

机构：

[1] HOWARD HUGHES MED INST,BETHESDA,MD 20892

[2] GEORGETOWN UNIV,SCH MED,DEPT PATHOL,WASHINGTON,DC 20057

[3] NICHHD,DEV & MOLEC IMMUN LAB,BETHESDA,MD 20892

[4] NATL INST MED RES,EUKARYOT MOLEC GENET LAB,LONDON NW7 1AA,ENGLAND

来源：

NATURE | 1990年 / 345卷 / 6277期

关键词：

D O I：

10.1038/345686a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes,oct-3 is expressed in the totipotent and pluripotent stem cells of the pre-gastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line. © 1990 Nature Publishing Group.

引用

页码：686 / 692

页数：7

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