RECEPTORS FOR INSULIN AND EPIDERMAL GROWTH FACTOR-UROGASTRONE IN ADULT HUMAN-FIBROBLASTS DO NOT CHANGE WITH DONOR AGE

被引：28

作者：

HOLLENBERG, MD

SCHNEIDER, EL

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT PHARMACOL & EXPTL THERAPEUT, BALTIMORE, MD 21205 USA

[2] NIA, GERONTOL RES CTR, BALTIMORE, MD 21224 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1979年 / 11卷 / 01期

关键词：

D O I：

10.1016/0047-6374(79)90062-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The ligand binding and biological responsiveness of cultured fibroblast monolayers were measured for porcine insulin and for murine epidermal growth factor-urogastrone in skin fibroblast cultures derived from young (22 to 31 years) and old (65 to 80 years) normal male volunteer donors. The receptor characteristics of the cells studied from the two groups of donors were not found to differ. In contrast with previous data, suggesting that there may be a genetically programmed aging of the insulin binding system, it is concluded that for both insulin and epidermal growth factor, receptor characteristics do not change with adult donor age. © 1979.

引用

页码：37 / 43

页数：7

共 24 条

[1]

CARPENTER G, 1975, J BIOL CHEM, V250, P4297

[2] I125 LABELED HUMAN EPIDERMAL GROWTH-FACTOR - BINDING, INTERNALIZATION, AND DEGRADATION IN HUMAN FIBROBLASTS [J].