THE ROLE OF CD4 AND CD8 T-CELLS IN VIRAL-INFECTIONS

被引：67

作者：

KOSZINOWSKI, UH ^{[1
]}

REDDEHASE, MJ ^{[1
]}

JONJIC, S ^{[1
]}

机构：

[1] UNIV RIJEKA, DEPT PHYSIOL & IMMUNOL, YU-51000 RIJEKA, CROATIA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1991年 / 3卷 / 04期

关键词：

D O I：

10.1016/0952-7915(91)90005-L

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Presentation of viral antigens to T cells does not require uptake by 'professional' antigen-presenting cells. Viruses have specialized to enter the cells in which they replicate. Virus entry, uncoating and new viral protein synthesis can load both the cytosolic and the endosomal pathway of antigen processing resulting in viral peptide presentation to CD8 and CD4 T cells by MHC class I and II molecules, respectively. Although a role of CD8 T cells in the control of viral infection has been well documented, current research interest centers on the contribution of the different CD4 T-cell subsets.

引用

页码：471 / 475

页数：5

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