DNA HLA-DR TYPING RESULTS OF 4000 KIDNEY-TRANSPLANTS

被引：51

作者：

MYTILINEOS, J

SCHERER, S

DUNCKLEY, H

TREJAUT, J

CHAPMAN, J

FISCHER, G

FAE, I

MIDDLETON, D

SAVAGE, D

BIGNON, JD

BENSA, JC

NOREEN, H

ALBERT, E

OPELZ, G

机构：

[1] UNIV SYDNEY,TRANSPLANT LAB,SYDNEY,NSW 2006,AUSTRALIA

[2] UNIV VIENNA,TRANSPLANT LAB,A-1010 VIENNA,AUSTRIA

[3] UNIV BELFAST,TRANSPLANT LAB,BELFAST,NORTH IRELAND

[4] UNIV NANTES,TRANSPLANT LAB,F-44035 NANTES,FRANCE

[5] UNIV GRENOBLE 1,TRANSPLANT LAB,F-38041 GRENOBLE,FRANCE

[6] UNIV MINNESOTA,TRANSPLANT LAB,MINNEAPOLIS,MN 55455

[7] UNIV MUNICH,TRANSPLANT LAB,W-8000 MUNICH 2,GERMANY

来源：

TRANSPLANTATION | 1993年 / 55卷 / 04期

关键词：

D O I：

10.1097/00007890-199304000-00018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recipients (4076) and donors (3325) of kidney transplants performed at 110 transplant centers were typed for HLA-DRB by the DNA RFLP method. The discrepancy rate of replicate samples distributed among 8 participating laboratories was a low 2.6%. The discrepancy rate between RFLP-DRB and serological HLA-DR typings was 25.0% for organ donors and 27.6% for kidney recipients. Discrepancy rates at the different transplant centers ranged from 9.7% to 86.7%. The discrepancies consisted of antigens being incorrectly interpreted by serology (16.8%), and of serological ''blanks'' turning out to be definable alleles by the DNA method (10.8%). The alleles that were mainly affected by discrepancies were DR1, DR8, DR10, DR12, DR13. DR14, DR16, DR17.2, and DR18.

引用

页码：778 / 781

页数：4

共 12 条

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