IMPAIRED CORPUS-LUTEUM FUNCTION AND OTHER UNDESIRED RESULTS OF PREGNANCIES ASSOCIATED WITH INADVERTENT ADMINISTRATION OF A LONG-ACTING AGONIST OF GONADOTROPIN-RELEASING-HORMONE

被引：31

作者：

HERMAN, A

RONEL, R

GOLAN, A

NACHUM, H

SOFFER, Y

CASPI, E

机构：

[1] Department of Obstetrics and Gynaecology, Assaf Harofe Medical Centre

[2] Sackler School of Medicine, Tel-Aviv University, Tel-Aviv

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 04期

关键词：

INADVERTENT GNRH; SPONTANEOUS PREGNANCY; CORPUS LUTEUM;

D O I：

10.1093/oxfordjournals.humrep.a137671

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Spontaneous pregnancies associated with inadvertent periconceptional administration of long-acting gonadotrophin releasing-hormone agonist (GnRHa), in in-vitro fertilization, occurred in 11 of 161 patients with non-tubal infertility. All these cases exhibited impaired function of the corpus luteum in terms of declining progesterone levels, despite rising levels of human chorionic gonadotrophin. The patients were categorized according to the timing of GnRHa administration: periovulatory (three cases), midluteal (five cases) and late luteal (three cases). Altogether, of the 11 pregnancies, seven ended with a normal livebirth, three with a preclinical gestation and one with a blighted ovum. It appears that spontaneous pregnancies associated with inadvertent administration of GnRHa are not rare. Awareness for early diagnosis and close hormonal monitoring are recommended for the assessment of corpus luteum function and adequate supplementation.

引用

页码：465 / 468

页数：4

共 21 条

[1]

Asch R.H., Siler-Khodr T.M., Smith C.G., Schaily A.V., Luteolytic effect of D-Trp6-luteinizing hormone-releasing hormone in the rhesus monkey (Macaco mulatto), J. Clin. Endocrinol. Metab, 52, pp. 565-571, (1981)

[2]

Casper R.F., Yen S., Induction of luteolysis in the human with a long-acting analog of luteinizing hormone-releasing factor, Science, 20, pp. 408-410, (1979)

[3]

Casper R.F., Sheehan K.L., Yen S.S.C., Chorionic gonadotropin prevents LRF-agonist-induced luteolysis in the human, Contraception, 21, pp. 471-479, (1980)

[4]

Caspi E., Ron-El R., Golan A., Nachum H., Herman A., Soffer Y., Weinraub Z., Results of in vitro fertilization and embryo transfer by combined long-acting gonadotropin-releasing hormone analog D-Trp-6-luteinizing hormone-releasing hormone and gonadotropins, Fertil. Steril, 51, pp. 95-99, (1989)

[5]

Clayton R.N., Huhtaniemi H.T., Absence of gonadotropinreleasing hormone receptors in human gonadal tissue, Nature, 29, pp. 56-59, (1982)

[6]

Dicker D., Goldman A., Vagman I., Eckstein N., Ayalon D., Pregnancy outcome following early exposure to maternal luteinizing- hormone-releasing hormone agonist, Hum. Reprod, 4, pp. 250-251, (1990)

[7]

Forman R., Robinson J., Eagen D., Ross C., Gosden B., Barlow D., Ectopic pregnancy after luteal phase initiation of gonadotropinreleasing hormone analog before in vitro fertilization, Fertil. Steril, 54, pp. 169-170, (1990)

[8]

Golan A., Ron-El R., Herman A., Weinraub Z., Soffer Y., Caspi E., Fetal outcome following inadvertent administration of long- acting D-Trp6 LH-RH microcapsules during pregnancy: A case report, Hum. Reprod, 5, pp. 123-124, (1990)

[9]

Happ J., Schultheiss H., Jacobi G.H., Pharmacodynamics, pharmacokinetics and bioavailability of prolonged LH-RH agonist Decapeptyl-SR, Raven Press, 18, (1987)

[10]

Lemay A., Labrie F., Belanger A., Raynaud J.P., Luteolytic effect of intranasal administration of [D-Ser(TBU)6, des-Gly- NH2l0]-luteinizing hormone-releasing hormone ethylamide in normal women, Fertil. Steril, 32, pp. 646-651, (1979)

← 1 2 3 →