APOLIPOPROTEIN E-4 GENE DOSE IN CLINICALLY DIAGNOSED ALZHEIMERS-DISEASE - PREVALENCE, PLASMA-CHOLESTEROL LEVELS AND CEREBROVASCULAR CHANGE

被引：55

作者：

CZECH, C

FORSTL, H

HENTSCHEL, F

MONNING, U

BESTHORN, C

GEIGERKABISCH, C

SATTEL, H

MASTERS, C

BEYREUTHER, K

机构：

[1] CENT INST MENTAL HLTH, DEPT PSYCHIAT, D-68159 MANNHEIM, GERMANY

[2] CTR MOLEC BIOL, D-69120 HEIDELBERG, GERMANY

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 1994年 / 243卷 / 05期

关键词：

ALZHEIMERS DISEASE; APOLIPOPROTEIN E-4; CHOLESTEROL; LEUKOARAIOSIS CEREBRAL INFARCT;

D O I：

10.1007/BF02191587

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The prevalence of the apolipoprotein E-4 allele (ApoE-4) was significantly higher in a referral population of 40 patients with clinically diagnosed Alzheimer's disease than in a sample of non-demented elderly controls (P < 0.01). The highest plasma cholesterol levels were found in demented patients homozygotic for Apo E-4, but no significant increases of glucose, triglycerides and thyroxine or of leuko-araiosis and brain infarcts were verified in this preliminary study.

引用

页码：291 / 292

页数：2

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