CHEMOTHERAPY PROLONGS SURVIVAL IN INOPERABLE PANCREATIC-CARCINOMA

被引:215
作者
PALMER, KR
KERR, M
KNOWLES, G
CULL, A
CARTER, DC
LEONARD, RCF
机构
[1] WESTERN GEN HOSP,DEPT CLIN ONCOL,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND
[2] WESTERN GEN HOSP,DEPT PSYCHOL,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND
[3] UNIV EDINBURGH,ROYAL INFIRM,DEPT SURG,EDINBURGH,SCOTLAND
关键词
D O I
10.1002/bjs.1800810629
中图分类号
R61 [外科手术学];
学科分类号
摘要
Forty-three patients with irrescetable advanced pancreatic cancer were randomized to receive chemotherapy using a combination of 5-fluorouracil, Adriamycin and mitomycin or no chemotherapy. Groups were well matched with regard to age, extent of disease and performance status on entry. Chemotherapy was well tolerated and, although common, side-effects were usually mild. Psychological measurements based on the Hospital Anxiety and Depression score were made in 31 patients. These showed significantly less depression but not anxiety in the treated group immediately after randomization and following 2 months of chemotherapy. Median survival in the treated group was 33 (range 9-80) weeks compared with 15 (range 1-62) weeks in the untreated group (P < 0.002). Chemotherapy should be considered in all patients presenting with advanced inoperable pancreatic cancer.
引用
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页码:882 / 885
页数:4
相关论文
共 26 条
[1]  
ARBUCK SG, 1990, INT J PANCREATOL, V7, P209
[2]   CHEMOTHERAPY FOR PANCREATIC-CANCER [J].
ARBUCK, SG .
BAILLIERES CLINICAL GASTROENTEROLOGY, 1990, 4 (04) :953-968
[3]  
BERNARD S, 1986, Proceedings American Society of Clinical Oncology Annual Meeting, V5, P84
[4]  
BITRAN JD, 1979, CANCER TREAT REP, V63, P2049
[5]  
BRENNAN MF, 1989, CANCER PRINCIPLES PR, P800
[6]  
BRUHL P, 1976, INT J CLIN PHARM BI, V14, P29
[7]  
BUKOWSKI RM, 1980, CANCER CLIN TRIALS, V3, P321
[8]   FACTORS INFLUENCING SURVIVAL AFTER PANCREATICODUODENECTOMY FOR PANCREATIC-CANCER [J].
CAMERON, JL ;
CRIST, DW ;
SITZMANN, JV ;
HRUBAN, RH ;
BOITNOTT, JK ;
SEIDLER, AJ ;
COLEMAN, J .
AMERICAN JOURNAL OF SURGERY, 1991, 161 (01) :120-125
[9]   INTEGRATION OF CHEMOTHERAPY INTO A COMBINED MODALITY APPROACH FOR CANCER TREATMENT .4. PANCREATIC ADENOCARCINOMA [J].
CARTER, SK ;
COMIS, RL .
CANCER TREATMENT REVIEWS, 1975, 2 (03) :193-214
[10]   SURVIVAL IN 1001 PATIENTS WITH CARCINOMA OF THE PANCREAS [J].
CONNOLLY, MM ;
DAWSON, PJ ;
MICHELASSI, F ;
MOOSSA, AR ;
LOWENSTEIN, F .
ANNALS OF SURGERY, 1987, 206 (03) :366-373