EXPRESSION OF ADHESION MOLECULE ICAM-1 (CD54) IN THYROID PAPILLARY ADENOCARCINOMA

被引：13

作者：

NAKASHIMA, M ^{[1
]}

EGUCHI, K ^{[1
]}

ISHIKAWA, N ^{[1
]}

YAMASHITA, I ^{[1
]}

SAKAI, M ^{[1
]}

IDA, H ^{[1
]}

KAWABE, Y ^{[1
]}

ITO, K ^{[1
]}

NAGATAKI, S ^{[1
]}

机构：

[1] ITO HOSP,TOKYO,JAPAN

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 1994年 / 17卷 / 11期

关键词：

ADHESION MOLECULE; ICAM-1; THYROID CANCER;

D O I：

10.1007/BF03347789

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The expression of adhesion molecules in thyroid specimens from 10 cases of papillary adenocarcinoma, 5 cases of follicular adenoma and 3 normal thyroid specimens was examined by an immunohistochemical method. Thyroid epithelial cells from all cases of papillary adenocarcinoma expressed the intercellular adhesion molecule 1 (ICAM-1, CD54). The ICAM-1-positive staining in these was detected predominantly on the apical site of malignant thyroid epithelial cells. However, no ICAM-1 expression was detected on thyrocytes of adenoma, and normal thyroid tissues. Furthermore, thyroid epithelial cells in patients with thyroid tumor and normal thyroid tissue did not react with anti-LFA-1, anti-VLA-LF, anti-VCAM-1 and anti-ELAM-1 monoclonal antibodies. It is speculated that ICAM-1 expression in thyroid papillary adenocarcinoma may have a functional significance.

引用

页码：843 / 848

页数：6

共 20 条

[1] INTEGRINS AND OTHER CELL-ADHESION MOLECULES [J].