BIOLOGICAL IMPLICATIONS OF ESTROGEN AND ANDROGEN EFFECTS ON ANDROGEN RECEPTOR AND ITS MESSENGER-RNA LEVELS IN HUMAN UTERINE ENDOMETRIUM

被引：14

作者：

FUJIMOTO, J

NISHIGAKI, M

HORI, M

ICHIGO, S

ITOH, T

TAMAYA, T

机构：

[1] Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 1995年 / 9卷 / 02期

关键词：

ANDROGEN RECEPTOR; ANDROGEN RECEPTOR MESSENGER-RNA; ESTROGEN AND ANDROGEN EFFECTS; UTERINE ENDOMETRIUM;

D O I：

10.3109/09513599509160205

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It has been shown that some effects of testosterone are different from those of its 5 alpha-reduced metabolite, dihydrotestosterone. Briefly, activities of testosterone might be related to cellular differentiation, whereas dihydrotestosterone acts on cellular proliferation. The number of testosterone binding sires in the uterine endometrium was increased by estradiol dipropionate, and this increase was down-regulated by testosterone cypionate. Dihydrotestosterone-specific binding sites in the endometrium were not modulated by estradiol dipropionate and testosterone cypionate. The dissociation constants of the bindings sites for testosterone and dihydrotestosterone were not altered by these steroids. Estradiol dipropionate with or without testosterone cypionate induced androgen receptor mRNA expression in the endometrium. In conclusion, testosterone might predominantly affect cellular differentiation in the endometrium.

引用

页码：149 / 155

页数：7

共 24 条

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