ASSOCIATION OF APOLIPOPROTEIN-E ALLELE EPSILON-4 WITH LATE-ONSET SPORADIC ALZHEIMERS-DISEASE

被引：44

作者：

LUCOTTE, G

VISVIKIS, S

LEININGERMULER, B

DAVID, F

BERRICHE, S

REVEILLEAU, S

COUDERC, R

BABRON, MC

AGUILLON, D

SIEST, G

机构：

[1] CTR PREVENT MED, VANDOEUVRE LES NANCY, FRANCE

[2] COURTABOEUF, EUROBIO LABS, LES ULIS, FRANCE

[3] TENON HOSP, SERV BIOCHEM, PARIS, FRANCE

[4] CHATEAU LONGCHAMP, GENET EPIDEMIOL UNIT, PARIS, FRANCE

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1994年 / 54卷 / 03期

关键词：

ALZHEIMERS DISEASE; APOLIPOPROTEIN E; EPSILON-4; ALLELE; LATE-ONSET AND SPORADIC FORMS; RISK FACTOR;

D O I：

10.1002/ajmg.1320540319

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Apolipoprotein E, type epsilon 4 allele (ApoE epsilon 4), is associated with late-onset sporadic Alzheimer's disease (AD) in French patients. The association is highly significant (0.45 AD versus 0.12 controls for epsilon 4 allele frequencies). These data support the involvement of ApoE epsilon 4 allele as a very important risk factor for the clinical expression of AD. (C) 1994 Wiley-Liss,Inc.

引用

收藏

页码：286 / 288

页数：3

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