N-15 AND H-1-NMR EVIDENCE FOR MULTIPLE CONFORMATIONS OF THE COMPLEX OF DIHYDROFOLATE-REDUCTASE WITH ITS SUBSTRATE, FOLATE

被引：21

作者：

BIRDSALL, B

DEGRAW, J

FEENEY, J

HAMMOND, S

SEARLE, MS

ROBERTS, GCK

COLWELL, WT

CRASE, J

机构：

[1] SRI INT,BIOORGAN CHEM LAB,MENLO PK,CA 94025

[2] SHELL RES LTD,SITTINGBOURNE RES CTR,DIV ANALYT CHEM,SITTINGBOURNE ME9 8AG,KENT,ENGLAND

[3] CANC INST,MELBOURNE,VIC 3000,AUSTRALIA

[4] UNIV LEICESTER,DEPT BIOCHEM,LEICESTER LE1 7RH,ENGLAND

来源：

FEBS LETTERS | 1987年 / 217卷 / 01期

关键词：

D O I：

10.1016/0014-5793(87)81252-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：106 / 110

页数：5

共 15 条

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[2] BEVAN AW, 1985, EUR BIOPHYS J BIOPHY, V11, P211
[3] H-1, C-13, AND P-31 NUCLEAR MAGNETIC-RESONANCE STUDIES OF THE DIHYDROFOLATE-REDUCTASE NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE FOLATE COMPLEX - CHARACTERIZATION OF 3 COEXISTING CONFORMATIONAL STATES
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[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1985, (07): : 1349 - 1353
[6] STEREOCHEMISTRY OF REDUCTION OF FOLIC-ACID USING DIHYDROFOLATE-REDUCTASE
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[7] LARGE-SCALE PURIFICATION AND CHARACTERIZATION OF DIHYDROFOLATE-REDUCTASE FROM A METHOTREXATE-RESISTANT STRAIN OF LACTOBACILLUS-CASEI
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OSTLER, G
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[J]. BIOCHEMICAL JOURNAL, 1976, 157 (03) : 559 - 571
[8] EFFECTS OF SOLVENT, PROTONATION, AND N-ALKYLATION ON N-15 CHEMICAL-SHIFTS OF PYRIDINE AND RELATED COMPOUNDS
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ROBERTS, JD
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (16) : 4969 - 4973
[9] FEENEY J, 1986, NMR LIVING SYSTEMS, P347
[10] Hitchings G. H., 1980, ENZYME INHIBITORS DR, P263

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