MUTAGENICITY STUDIES WITH X-RAY-CONTRAST MEDIA, ANALGESICS, ANTI-PYRETICS, ANTI-RHEUMATICS AND SOME OTHER PHARMACEUTICAL DRUGS IN BACTERIAL, DROSOPHILA AND MAMMALIAN TEST SYSTEMS

被引：68

作者：

KING, MT

BEIKIRCH, H

ECKHARDT, K

GOCKE, E

WILD, D

机构：

[1] Zentrallaboratorium für Mutagenitätsprüfung der Deutschen Forschungsgemeinschaft, Freiburg

来源：

MUTATION RESEARCH | 1979年 / 66卷 / 01期

关键词：

D O I：

10.1016/0165-1218(79)90005-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

As part of our investigation into mutagenic effects of environmental compounds, we studied 21 pharmaceuticals most frequently sold in West Germany: 6 X-ray-contrast media, 13 analgesics, antipyretics and antirheumatics, 1 central stimulant, and 1 antidepressant. They were studied in different bacterial, Drosophila and mammalian test systems. 4 of these 21 compounds could be detected as mutagens in one of the test systems. namely: 1,2-dichloroethane induced an increase in the frequency of recessive sex-linked lethal mutations in Drosophila melanogaster, quinine dihydrochloride and dimethylaminophenazone were mutagenic in the Salmonella typhimurium tester strain TA98 in the presence of S-9 liver fraction derived from Aroclor-induced rats, and trilithium citrate caused a significant effect in the micronucleus test on bone marrow of NMRI mice. © 1979.

引用

页码：33 / 43

页数：11

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