MULTIPLE COMPONENT ANALYSIS OF PLASMA GROWTH-HORMONE IN CHILDREN WITH STANDARD AND SHORT STATURE

被引：15

作者：

AYALA, DE

HERMIDA, RC

GARCIA, L

IGLESIAS, T

LODEIRO, C

机构：

[1] ETSI Telecommunicatioan, Univ. Vigo, Vigo

[2] Centro OncoloAgico de Galicia, La CorunTa

来源：

CHRONOBIOLOGY INTERNATIONAL | 1990年 / 7卷 / 03期

关键词：

Circadian; Key words-Growth hormone; Multiple component analysis; Short stature; Standard stature; Ultradian;

D O I：

10.3109/07420529009056977

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Growth hormone (GH) concentrations (in ng/ml) were determined by radioimmunoassay, in plasma obtained at about 3-hr intervals during a 24-hr sampling span, from 42 boys and 12 girls of short stature (2-4 standard deviations below their peer group mean), and 13 boys and 9 girls of standard stature. Subjects had 11.20 0.37 years of age at the time of study, and were living on a diurnal waking (∼07:30 to ∼22:30), nocturnal resting routine during sampling. Analysis of these data by single and population-mean cosinor methods as well as by analysis of variance revealed circadian and ultradian prominent components characterizing most groups. Accordingly, a multiple component analysis was undertaken for data of each group separately, as well as for all subjects. A comparison of circadian parameters indicates similar characteristics between short and standard children, whether one compares boys [P=0.674, 0.371 and 0.749 for comparison of rhythm adjusted means (M), amplitudes (A) and acrophases (), respectively], girls (P=0.993,0.914 and 0.397), or all children (P=0.859,0.712 and 0.865). Differences are found, however, in circasemidian characteristics as well as in the prominent 8-hr ultradian component documented for the short but not for the standard children. These ultradian components should be taken into consideration in the design and later evaluation of a time-specified treatment of children of short stature. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：217 / 220

页数：4

共 11 条

[1] Hermida R.C., GarcIa L., Lodeiro C., Iglesias T., Circadian and ultradian characteristics of plasma growth hormone in children of short stature, Annual Review of Chronopharmacology, 5, pp. 81-84, (1988)
[2] Hermida R.C., GarcIa L., Lodeiro C., Ayala D.E., Iglesias T., Halberg F., Circadian and ultradian characteristics of plasma growth hormone in children with normal and short stature, J. Endocrinol. Invest., 12, pp. 69-73, (1989)
[3] Lodeiro C., Garcia L., Hermida R.C., Iglesias T., Halberg F., Correlation of MESOR with circadian amplitude of plasma growth hormone in children of short stature, Chronobiologia, 14, (1987)
[4] Rochiccioli P.E., Tauber M.T., Uboldi F., Coude F.X., Morre M., Effect of overnight constant infusion of human growth hormone (GH)-releasing hormone-(1–44) on 24-hour GH secretion in children with partial GH deficiency, J. Clin. Endocrinol. Metab., 63, pp. 1100-1105, (1986)
[5] Iglesias T., Hermida R.C., GarcIa L., Lodeiro C., Ayala D.E., FernANdez J.R., Circannual rhythm of plasma growth hormone in girls (but not boys) with constitutional short stature, Chronobiologia, 16, pp. 146-147, (1989)
[6] Hermida R.C., Chronobiologic data analysis systems with emphasis in chronotherapeutic marker rhythmometry and chronoepidemiologic risk assessment, Chronobiotechnology and Chronobiological Engineering., pp. 88-119, (1987)
[7] Tong Y.L., Nelson W., Sothern R.B., Halberg F., Estimation of the orthophase (timing of high values) on a non-sinusoidal rhythm-illustrated by the best timing for experimental cancer chronotherapy, pp. 765-769, (1977)
[8] Hermida R.C., GarcIa L., FernANdez J.R., Ayala D.E., Software system for marker rhythmometry in pediatrics, Proc. IASTED Int. Symp. On Applied Informatics., pp. 238-242, (1989)
[9] Nelson W., Tong Y.L., Lee J.K., Halberg F., Methods for cosinor rhythmometry, Chronobiologia, 6, pp. 305-323, (1979)
[10] Bingham C., Arbogast B., Cornelissen G., Lee J.K., Halberg F., Inferential statistical methods for estimating and comparing cosinor parameters, Chronobiologia, 9, pp. 397-439, (1982)

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