ALPHA-TOCOPHEROL SUPPORTS THE SURVIVAL AND NEURITE EXTENSION OF NEURONS CULTURED FROM VARIOUS REGIONS OF FETAL-RAT BRAIN

被引：17

作者：

NAKAJIMA, M ^{[1
]}

KASHIWAGI, K ^{[1
]}

HAYASHI, Y ^{[1
]}

SAITO, M ^{[1
]}

KAWASHIMA, T ^{[1
]}

FURUKAWA, S ^{[1
]}

KOBAYASHI, K ^{[1
]}

机构：

[1] GIFU PHARMACEUT UNIV,DEPT MOLEC BIOL,GIFU 502,JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 133卷 / 01期

关键词：

ALPHA-TOCOPHEROL; ANTIOXIDANT; NEURONAL CULTURE; NEURITE EXTENSION; NEURONAL SURVIVAL; FETAL RAT BRAIN;

D O I：

10.1016/0304-3940(91)90054-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of alpha-tocopherol on neurons of fetal rat brain were studied in tissue culture. Alpha-Tocopherol supported the survival and enhanced neurite extension of neurons cultured from cerebral cortex, hippocampus, striatum, and septum. The survival effect was observed at concentrations of 10(-9) to 10(-6) M. More than 60% of the cortical neurons could survive for 9 days at 10(-7) or 10(-6) M alpha-tocopherol, whereas almost all neurons died within 2 days in its absence. These results suggest that alpha-tocopherol may be involved in mechanisms regulating neuronal survival and neurite formation in the central nervous system, and indicate that alpha-tocopherol may be an excellent reagent to facilitate neuronal survival in culture.

引用

页码：49 / 52

页数：4

共 21 条

[1] EFFECTS OF RECOMBINANT HUMAN BASIC FIBROBLAST GROWTH-FACTOR AND ITS MODIFIED PROTEIN CS23 ON SURVIVAL OF PRIMARY CULTURED NEURONS FROM VARIOUS REGIONS OF FETAL-RAT BRAIN [J].